diff --git a/source/blender/editors/interface/interface_layout.cc b/source/blender/editors/interface/interface_layout.cc
index 0e80e153235..9047e774498 100644
--- a/source/blender/editors/interface/interface_layout.cc
+++ b/source/blender/editors/interface/interface_layout.cc
@@ -6144,8 +6144,9 @@ static void ui_paneltype_draw_impl(bContext *C, PanelType *pt, uiLayout *layout,
     ui_block_add_dynamic_listener(block, pt->listener);
   }
 
-  /* This check may be paranoid, this function might run outside the context of a popup. */
-  if (block->handle) {
+  /* This check may be paranoid, this function might run outside the context of a popup or can run
+   * in popopers that are not supposed to support refreshing, see #ui_popover_create_block. */
+  if (block->handle && block->handle->region) {
     /* Allow popovers to contain collapsible sections, see #uiItemPopoverPanel. */
     UI_popup_dummy_panel_set(block->handle->region, block);
   }